As disconnected and lost as this book has felt from either the Avengers family of books or the X-Men family of books, I simply can not believe that editorial would allow Rick Remender to kill off so many characters at one time, and with so little marketing fanfare ahead of time.
This story line is far from complete, so that also leads me to believe that there is no way all/any of these characters are dead. This issue opens up with four full pages of Kang traveling through time saving people, so that alone is enough of a hint to tell readers that the events of this issue are easily reversible...at least, I believe that they are.
Wanda Maximoff hasn't been back around long enough to kill her, as the Scarlett Witch is in the process of rebuilding as a character, particularly for this generation of readers. She hasn't been around much since M Day, and while her role in AvX was substantial, she hasn't been developed that much since then. Her relationship with Wonder Man has been the crux of her existence here in Uncanny Avengers, and that also leads me to believe that these deaths are red herrings. It's apparent that Remender tends to build on the relationship between Wonder Man and the Scarlett Witch, so killing both of them off in the same issue just seems unlikely.
And then there's Rogue. She's Rogue. That's all the explanation I really need. I can't see editorial allowing her to be killed off in anything other than a major event that sells through hundreds of thousands of copies. Oh, and she had absorbed Wolverine's powers before her impaling by Grim Reaper. Healing factor, anyone?
So yeah, this was the most interesting issue of Uncanny Avengers so far, but it all seems to well set up to be quickly undone via time travel, and my guess is that that's what will happen, except with Rogue, who I don't think is dead due to healing factor.
Also of note, Steve McNiven's art in this is absolutely amazing. I'm so glad he has joined this book, I hope his run is a long one.