Well, it's been a while since I read a comic this bad. It felt like a chore to make it to the end of this regular-sized 20 page first issue , and I definitely won't be picking up issue #2 to see where this goes.
Kelly Sue DeConnick has written numerous comics that I have enjoyed over the years, but this doesn't happen to be one of them. The story telling is confusing and muddled, often losing itself in flowery prose and poem, and when it does find its footing, it is uninteresting and as unoriginal as I can imagine.
The art is equally yawn-inducing, primarily because of the awful coloring. The washed out, muted and severely limited color palette are likely intended to make this book look old since it is set in the old west, but instead just adds to the drab affair that is Pretty Deadly.
Even the lettering is offensively mundane, doing nothing to add to an overwhelmingly boring narrative and artistic experience.
I struggled to reach the end of this first issue, and that's almost never a problem with a first issue, because at least the newness of a #1 is enough to keep you engaged for at least 20 pages, or if not, the hope of a decent ending to maybe get you to read one more issue is still there. Alas, I lost that hope early in here, and this book never did give me a reason to go any further.
I think the last time I read a first issue that was this bad was Morbius #1 last November (or somewhere around then) from Marvel.
I would really suggest that you stay away from this...it's terrible.